How does circadian clock control my body?
The rotation of the earth creates a daily fluctuation of environmental cues, and organisms have evolved internal timing systems, called circadian clocks, to coordinate their daily activities to anticipate and prepare for these environmental changes. Because circadian rhythmicity is a fundamental aspect of temporal organization in essentially every cell in the body, and governs many biological processes ranging from molecular and biochemical pathways to physiological and behavioral rhythms, disruption of the circadian clock can have a severe influence on human health, ranging from psychiatric disorders, obesity, cardiovascular diseases, to certain types of cancer.
The mission of the Kojima laboratory is to understand how the molecular clock machinery in each cell controls circadian biochemistry, physiology and ultimately behavior at a molecular level. We specifically focus on rhythmic gene expression in various mouse tissues, with a special emphasis on transcription-independent gene regulatory mechanisms. Our approach integrates diverse techniques that will bridge traditional disciplinary boundaries such as neuroscience, molecular/cellular biology, physiology, and genomics, and particularly take advantage of state-of-the-art techniques such as next-generation sequencing technologies.
Also visit my BI webpage:
Feb. 2018 Our mathematical paper for sense-antisense Period gene is out!
Read here: https://doi.org/10.1371/journal.pcbi.1005957
Feb. 2018 Kijana George (TBMH program) is rotating with us. Welcome!
Jan. 2018 Akari Ueda and Tsubasa Toda are visiting us for 6 weeks from Toyohashi University of Technology. Welcome!